+49A/G -318C/T CT60A/G CTLA-4 ankylosing spondylitis. In summary, there existed significant association between CTLA-4 gene polymorphisms and increased or decreased risk for AS. However, the T allele of -318C/T appeared to be a protective factor for AS (OR=0.383, 95% CI=0.228-0.643). Moreover, the frequency of A allele was also presented as a risk factor for AS. The genotype analysis showed that AA genotype of + 49A/G polymorphism could increase the risk for AS (OR=2.357, 95% CI=1.127-4.930). In our study, genotype distribution of the three polymorphisms in control group was consistent with the HWE (P > 0.05). Restriction fragment length polymorphism. Odds ratio (OR) with 95% confidence interval (95% CI) were adopted to evaluate the relationship of CTLA-4 polymorphisms and AS susceptibility. Genotype distribution in control group was assessed by Hardy Weinberg Equilibrium (HWE) test. This article presents a clear set of laboratory exercises designed to introduce students to the use of polymerase chain reaction-restriction-fragment length polymorphism (PCR-RFLP) as a means of detection of genetic variants. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) were used to determine the gentypes of +49A/G, -318C/T and CT60A/G polymorphisms. However, the time limit of Biochemistry labs for undergraduate students represents a major obstacle. 820 additional restriction fragment length polymorphisms (rfls)for detection of ornithine transcarbamylase (otc) deficiency. The aim of our study was to evaluate the association between CTLA-4 polymorphisms (+49A/G, -318C/T and CT60A/G) and ankylosing spondylitis (AS) susceptibility.Ī total of 120 AS cases and healthy controls, matched on the age and gender, were enrolled in the study. 818 analysis of a hindi ii polymorphism in the humantype ii collagen gene in.
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